Abstract
A novel series of 6-bicyclopiperazinyl-1-arylsulfonylindoles and 6-bicyclopiperidinyl-1-arylsulfonylindoles derivatives was synthesized and found to be potent and selective 5-HT6 receptor antagonists.
MeSH terms
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Cell Line
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Humans
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Indoles / chemical synthesis
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Indoles / chemistry
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Indoles / metabolism
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Indoles / pharmacology*
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Piperazines / chemistry
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Radioligand Assay
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Receptors, Serotonin / drug effects*
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Receptors, Serotonin / metabolism
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Serotonin Antagonists / chemical synthesis
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Serotonin Antagonists / chemistry
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Serotonin Antagonists / pharmacology*
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Sulfones / chemistry
Substances
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Indoles
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Piperazines
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Receptors, Serotonin
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Serotonin Antagonists
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Sulfones
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serotonin 6 receptor